Plasma protein binding and drug distribution #pharmacology #pharmacy #pharmacokinetics

3-Second Blueprint (English)

1. To exit blood vessels, drug molecules must be small enough to pass through capillary fenestrations or intercellular spaces.
2. In the bloodstream, drugs bind plasma proteins such as albumin and globulins, splitting into protein-bound and free fractions.
3. Because bulky drug-protein complexes cannot cross vascular pores, only the unbound free drug distributes into target tissues.