How the brain makes decisions - in the pre-frontal cortex

3-Second Blueprint (English)

1. Within the prefrontal cortex mosaic, the lateral orbitofrontal cortex links specific choices and stimuli to their causal outcomes.
2. Primate reward-learning experiments and targeted disruptions show this region is crucial for associating an action with its reward.
3. Human fMRI, focal stroke studies, and research on causal self-blame in depression connect orbitofrontal circuits to mental illness.