Cyclooxygenase-1 & Cyclooxygenase-2 (COX 1, COX 2) - All You Need To Know - Pharmacology

3-Second Blueprint (English)

1. Phospholipase A2 frees arachidonic acid from membrane phospholipids so COX enzymes can form prostaglandins and thromboxanes.
2. Platelet thromboxane A2 drives vasoconstriction and clotting, while endothelial prostacyclin dilates vessels and blocks clots.
3. Non-selective NSAIDs raise ulcer and bleeding risk by blocking COX-1, while selective COX-2 inhibitors raise clotting risk.